… Point mutations in genes involved in resistance to … chromosome aneuploidies leading to
copy number variations of … albicans isolates are compared with the genome (haplotype A) of …

… An RNAi inactivating point mutation is present in the … This regulatory mechanism could
potentially change TLO copy numbers … albicans is phased, only haplotype A was used for the read …

… to hold haplotypes constant, we introduced more mutations that … While many organisms
spend the majority of their life with one copy … The point mutations for all lines are available in the …

… albicans aneuploid strains, each carrying one extra copy of … 19 isolates identified a total of
386 mutations compared to the … rule out the possible contributions of some point mutations. …

… between commercial starter haplotypes coupled with … inspired by the quartet subtree approach
for comparing topologies [80] … copy number values (0.5 read depth difference from 2N per …

… In a second round of copy retrieval, we used the same approach … In a previous study of
Saccharomyces cerevisiae, it was … minimum size (-s) of 4 kb and extending the haplotypes by 2 kb …

… approach to compare each strain’s haplotypes with their closest match in the clades described
in the 1,011 S. … or red cross on the strains that harbor at least one inactivated copy. The …

… or segmental chromosome copy number differences between … sublineages identified by
shared point mutations and their … studied in bacteria and Saccharomyces cerevisiae (39, 40). …

… Candida albicans, orthologs are usually compared with Saccharomyces cerevisiae, and
this approach has … albicans SC5314 haplotype A, version A22, downloaded from the CGD ( …

… on their presence on long shared haplotypes have a lower ts/tv … , they include two euploid
strains per clade without any copy … We found the spectra of point mutations we measured from …